Effect of Passive Smoking on Oxidative Stress and Dental Caries in Children
1 other identifier
observational
180
0 countries
N/A
Brief Summary
The purpose of the present study was to determine the effect of passive smoking on oxidative stress and dental caries in children.A total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalence of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Nov 2016
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 16, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 15, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
August 15, 2018
CompletedFirst Submitted
Initial submission to the registry
March 4, 2020
CompletedFirst Posted
Study publicly available on registry
March 6, 2020
CompletedMarch 9, 2020
March 1, 2020
1.4 years
March 4, 2020
March 5, 2020
Conditions
Outcome Measures
Primary Outcomes (3)
determining oxidative stress marker in saliva: TAS
Unstimulated saliva samples were collected from children.
1 day (once after the dental examination)]
determining oxidative stress marker in saliva: TOS
Unstimulated saliva samples were collected from children.
1 day (once after the dental examination)
determining caries prevalence
Children were examined to determine caries prevalence.
1 day (once for dental examination)
Study Arms (2)
study group (passive smoking children)
examining for caries prevalence and taking saliva samples to determine oxidative stress markers TAS and TOS
control group
examining for caries prevalence and taking saliva samples to determine oxidative stress markers TAS and TOS
Interventions
Eligibility Criteria
Children, referring for dental examination to the Department of Pediatric Dentistry of Kirikkale University, were selected.
You may qualify if:
- Systemically healthy children
You may not qualify if:
- Uncooperative children
- The presence of orthodontic/intraoral appliance
- Any disease or condition known to affect oxidative stress
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Merve Erkmen Almazlead
- Kırıkkale Universitycollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assist prof
Study Record Dates
First Submitted
March 4, 2020
First Posted
March 6, 2020
Study Start
November 16, 2016
Primary Completion
April 15, 2018
Study Completion
August 15, 2018
Last Updated
March 9, 2020
Record last verified: 2020-03